Authors

Anatte E. Karmon, M.D., Maria Batsis, M.D., Jorge E. Chavarro, M.D., Sc.D., Irene Souter, M.D.

Volume 103, Issue 1, Pages 258-263

Abstract

Objective:

To evaluate differences in intrauterine insemination (IUI) outcomes among euthyroid women with preconceptional thyroid-stimulating hormone (TSH) values in the normal (0.4–2.4 mIU/L) and high-normal (2.5–4.9 mIU/L) ranges.

Design:

Cohort study.

Setting:

A single fertility center.

Patient(s):

A total of 1,477 women who underwent 4,064 IUI cycles between the years 2004 and 2012.

Intervention(s):

None.

Main Outcome Measure(s):

Live birth, clinical pregnancy, spontaneous abortion (SAB), and IUI cycle parameters.

Result(s):

Cycles were categorized into 4 groups based on preconceptional TSH values: 0.40–1.36 mIU/L; 1.37–1.86 mIU/L; 1.87–2.49 mIU/L; and 2.50–4.99 mIU/L. No statistically significant differences were found in IUI cycle parameters, clinical pregnancy rates, or live births per initiated cycle among the 4 TSH groups. However, preconceptional TSH was inversely related to SAB and positively related to live birth among women who achieved a clinical pregnancy. In this group of women, cycles with TSH values between 2.5 and 4.9 mIU/L were related to lower odds of SAB (odds ratio: 0.32; 95% confidence interval: 0.16–0.65) and higher odds of live birth (odds ratio: 2.80; 95% confidence interval: 1.43–5.48) compared with cycles among women in the lowest TSH group.

Conclusion(s):

Among euthyroid patients, preconceptional TSH values in the high-normal range (between 2.5 and 4.9 mIU/L) are not associated with adverse IUI outcomes.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)02212-2/fulltext