Calcium infusion for the prevention of ovarian hyperstimulation syndrome A double blind randomized controlled trial

Intravenous calcium infusion effectively reduced the incidence of ovarian hyperstimulation syndrome development without reduction in the pregnancy rate.

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Authors

Waleed El-Khayat, M.D., Mostafa Elsadek, M.D.

Volume 103, Issue 1, Pages 101-105

Abstract

Objective:

To evaluate the role of calcium infusion as a preventive strategy of ovarian hyperstimulation syndrome (OHSS) in women at high risk in in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment cycles.

Design:

Double-blinded randomized controlled trial.

Setting:

University hospital department of obstetrics and gynecology and private IVF center.

Patient(s):

Two hundred women at risk to develop OHSS undergoing IVF/ICSI treatment cycle.

Intervention(s):

The intervention group (group 1; n = 100) received intravenous infusion of 10 mL 10% calcium gluconate in 100 mL 0.9% saline solution on the day of ovum pick-up (OPU) and days 1, 2, and 3 after, and the placebo group (group 2; n = 100) received 100 mL 0.9% saline solution on the day of OPU and days 1, 2, and 3 after.

Main Outcome Measure(s):

Incidence of OHSS.

Result(s):

OHSS incidence was significantly higher in the placebo group (group 2) than in the calcium infusion group (group 1): 23 (23%) vs. 7 (7%); moderate OHSS was significantly higher in group 2 than in group 1: 8 (8%) vs. 1 (1%); and severe OHSS was significantly higher in group 2 than in group 1: 4 (4%) vs. 0.

Conclusion(s):

Intravenous calcium infusion effectively reduced the incidence of OHSS development without reduction in the pregnancy rate.

Clinical Trial Registration Number:

NCT01427335.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)02266-3/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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