Are semen parameters related to birth weight

Birth weight of men with unexplained subfertility is positively correlated with sperm DNA fragmentation in adulthood. In utero environment and its relation to semen parameters may be considered in subfertility.

Like Comment

Authors

Céline Faure, Ph.D., Charlotte Dupont, Pharm.D., Pascale Chavatte-Palmer, D.V.M., Benoit Gautier, M.Sc., Rachel Levy, M.D. for the ALIFERT Collaborative Group

Volume 103, Issue 1, Pages 6-10

Abstract

Several experimental models suggest a link between maternal nutrition during gestation and reproductive function in offspring, but the impact of birth weight on male fertility in adulthood in humans is poorly documented. To study whether birth weight is associated with unexplained male subfertility later in life, we evaluated the relationship between birth weight and sperm parameters in adulthood in white subfertile men, partners of couples with primary idiopathic subfertility, and fertile men recruited within the ALIFERT (Diet and Its Relationship with Couple Infertility) study. Total sperm count, progressive motility, and sperm DNA fragmentation were analyzed in sperm, and metabolic assays were performed on blood. Birth weight was associated with sperm DNA fragmentation and inversely correlated with total sperm count, underlining the importance of the in utero environment for male reproductive function.

Clinical Trial Registration Number:

NCT01093378.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)02383-8/fulltext


Go to the profile of Fertility and Sterility

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.