Increased expression of antimullerian hormone and its receptor in endometriosis

Endometrium and endometriotic lesions express high levels of antim€ullerian hormone and its receptor, without any contribution to circulatory levels.

Like Comment

Authors

Patrizia Carrarelli, M.Sc., Ana Luiza Lunardi Rocha, M.D., Giuseppe Belmonte, M.Sc., Errico Zupi, M.D., Mauricio Simoẽs Abrão, M.D., Felice Arcuri, Ph.D., Paola Piomboni, Ph.D., Felice Petraglia, M.D.

Volume 101, Issue 5, Pages 1353–1358

Abstract

Objective:

To evaluate antimüllerian hormone (AMH) and AMH receptor II (AMHRII) mRNA and protein expression in endometrium and in ovarian or deep lesions of women with endometriosis.

Design:

Prospective study.

Setting:

University hospitals in Italy and Brazil.

Patients:

Patients with endometriosis (n = 55) and healthy women (n = 45).

Interventions:

Specimens of endometrium obtained by hysteroscopy from patients with endometriosis and from healthy control subjects; specimens of ovarian endometriosis (n = 29) or of deep endometriosis (n = 26) were collected by laparoscopy. Serum samples were collected in some endometriotic patients (n = 23) and healthy control subjects (n = 20).

Main Outcome Measure(s):

AMH and AMHRII mRNA levels were evaluated by quantitative reverse-transcription polymerase chain reaction and protein localization by immunohistochemistry. AMH levels in tissue homogenates and in serum were assessed by ELISA.

Result(s):

Endometrium from women with endometriosis showed higher AMH and AMHRII mRNA levels than control women, with no significant differences between proliferative and secretory phases. Specimens collected from ovarian or deep endometriosis showed the highest AMH and AMHRII mRNA expression. Immunolocalization study confirmed the high AMH and AMHRII protein expression in endometriotic lesions. No difference of serum AMH levels between the groups was found.

Conclusion(s):

The increased AMH and AMHRII mRNA and protein expression in endometrium and in endometriotic lesions suggests a possible involvement of AMH in endometriosis.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)00100-9/fulltext


Go to the profile of Fertility and Sterility

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.