Effect of oocyte donation on pregnancy outcomes in in vitro fertilization twin gestations

In patients who conceive twin pregnancies using IVF, oocyte donation increases the risk of gestational hypertension and preeclampsia.

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Lucky H. Sekhon, M.D., Rachel S. Gerber, M.D., Andrei Rebarber, M.D., Daniel H. Saltzman, M.D., Chad K. Klauser, M.D., Simi Gupta, M.D., Nathan S. Fox, M.D.

Volume 101, Issue 5, Pages 1326–1330



To estimate the effect of oocyte donation on pregnancy outcomes in patients with twin pregnancies conceived via IVF.


Retrospective cohort study.


Patients with IVF twin pregnancies delivered by one maternal–fetal medicine practice from 2005 to 2013.


Fifty-six patients with IVF twin pregnancies who had oocyte donation and 56 age-matched controls with IVF twin pregnancies who used autologous oocytes. We excluded women aged >50 years because there were no age-matched controls aged >50 years using autologous oocytes.



Main Outcome Measure(s):

Gestational hypertension, pre-eclampsia.


The baseline characteristics were similar between the groups, including maternal age, race, parity, chorionicity, and comorbidities. The mean (±SD) age was 43.0 ± 6.0 vs. 41.9 ± 1.7 years. There were no differences in outcomes between the groups in regard to preterm birth, birth weight, or gestational diabetes. There was a greater incidence of gestational hypertension (32.1% vs. 13.0%) and pre-eclampsia (28.3% vs. 13.0%) in the group that underwent IVF with donor oocytes.


In patients who conceive twin pregnancies using IVF, oocyte donation increases the risk of gestational hypertension and pre-eclampsia. However, this did not translate into increased rates of preterm birth or low birth weight. Patients who require oocyte donation should be carefully counseled regarding the increased risk for pre-eclampsia and gestational hypertension but should be reassured that oocyte donation does not seem to lead to other adverse outcomes.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)00103-4/fulltext

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.