Effect of prior oophorectomy on changes in bone mineral density and carotid artery intima media thickness in postmenopausal women

Secondary analysis of the Women’s Isoflavone Soy Health trial demonstrates that as menopausal onset increases in healthy postmenopausal women, oophorectomy is associated with faster rates of bone loss and carotid artery intima-media thickening.

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Authors

Sara J. Mucowski, M.D., Wendy Mack, Ph.D., Donna Shoupe, M.D., M.B.A., Naoko Kono, M.P.H., Richard Paulson, M.D., Howard N. Hodis, M.D.

Volume 101, Issue 4, Pages 1117-1122

Abstract

Objective:

To determine the effect of prior oophorectomy in healthy postmenopausal women on the rate of loss of bone mineral density (BMD) and rate of increase in carotid artery intima-media thickness (CIMT).

Design:

Secondary analysis from a randomized controlled trial.

Setting:

University-based research clinic.

Patient(s):

Two hundred twenty-two healthy postmenopausal women in the Greater Los Angeles area.

Intervention(s):

Baseline and annual screening of BMD and assessment of CIMT every 6 months for a total of 3 years.

Main Outcome Measure(s):

Changes in BMD and CIMT during postmenopausal years.

Result(s):

Among women who were menopausal for more than 10 years, the rate of CIMT progression was statistically significantly less in women with intact ovaries compared with those in women with prior oophorectomy. In women 5–10 years postmenopause, there was a trend toward a slower loss of BMD in those who retained their ovaries, and in women more than 10 years postmenopause there was significantly less BMD loss in those who retained their ovaries.

Conclusion(s):

As time from menopausal transition increases, retained ovaries are associated with a slower rate of bone loss and a slower rate of thickening of the carotid artery wall compared with rates in menopausal women with oophorectomy.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)00002-8/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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