Maternal characteristics and pregnancy outcomes after assisted reproductive technology by infertility diagnosis ovulatory dysfunction versus tubal obstruction

This study examined the differences in maternal characteristics and pregnancy outcomes between women with ovulatory dysfunction and tubal obstruction who underwent assisted reproductive techniques.

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Violanda Grigorescu, M.D., M.S.P.H., Yujia Zhang, Ph.D., Dmitry M. Kissin, M.D., M.P.H., Erin Sauber-Schatz, Ph.D., M.P.H., Mithi Sunderam, Ph.D., M.A., Russell S. Kirby, Ph.D., M.S., Hafsatou Diop, M.D., M.P.H., Patricia McKane, D.V.M., M.P.H., Denise J. Jamieson , M.D., M.P.H.

Volume 101, Issue 4, Pages 1019-1025



To examine differences in maternal characteristics and pregnancy outcomes between women with ovulatory dysfunction (OD) and women with tubal obstruction (TO) who underwent assisted reproductive technology (ART).


Retrospective cohort study.


Centers for Disease Control and Prevention.


Exposed and nonexposed groups were selected from the 2000–2006 National ART Surveillance System linked with live-birth certificates from three states: Florida, Massachusetts, and Michigan.



Main Outcome Measure(s):

Maternal characteristics and pregnancy outcomes, including newborn’s health status right after delivery (Apgar score, <7 vs. ≥7) as the study outcome of interest, were assessed among women with OD/polycystic ovary syndrome (PCOS) and TO who used ART. Result(s):

A significantly higher prevalence of women with OD/PCOS were younger (<35 years of age; 65.7% vs. 48.9%), were white (85.4% vs. 74.4%), had higher education (29.4% vs. 15.6%), and experienced diabetes (8.8% vs. 5.3%) compared with those having TO. The odds of having a lower (<7) Apgar score at 5 minutes were almost twice as high among newborns of women with OD/PCOS compared with those with TO (crude odds ratio, 1.86; 95% confidence interval [CI], 1.31, 2.64; adjusted odds ratio, 1.90; 95% CI, 1.30, 2.77). Conclusion(s):

Women with OD/PCOS who underwent ART have different characteristics and health issues (higher prevalence of diabetes) and infant outcomes (lower Apgar score) compared with women with TO.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.