Prognosis factors of pregnancy after intrauterine insemination with the husbands sperm Conclusions of an analysis of 2019 cycles

Positive predictive factors of pregnancy after IUI-H were woman’s secondary infertility, woman basal FSH levels 7 IU/L, ovulation triggering and inseminated progressive motile spermatozoa 1 million.

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Authors

Laka Dinelli, M.D., Blandine Courbiere, M.D., Ph.D., Vincent Achard, M.D., Ph.D., Elisabeth Jouve, M.Sc., Carole Deveze, M.D., Audrey Gnisci, M.D., Jean-Marie Grillo, M.D., Ph.D., Odile Paulmyer-Lacroix, M.D., Ph.D.

Volume 101, Issue 4, Pages 994-1000

Abstract

Objective:

To identify the prognostic factors for pregnancy after intrauterine insemination with the husband’s sperm (IUI-H).

Design:

Retrospective study.

Setting:

A single university medical center.

Patient(s):

851 couples, for 2,019 IUI-H cycles.

Intervention(s):

After controlled ovarian stimulation, IUI-H performed 36 hours after ovulation triggering or 24 hours after a spontaneous luteinizing hormone (LH) surge.

Main Outcome Measure(s):

Clinical pregnancy rate per cycle (PR) and delivery rate per cycle (DR).

Result(s):

The overall PR was 14.8% and DR 10.8%. Higher PR and DR were observed for patients presenting with ovulation disorders (particularly polycystic ovary syndrome) or with male infertility. Secondary infertility in the woman appeared to be a positive prognostic factor as did a basal follicle-stimulating hormone (FSH) level ≤7 IU/L and ovulation triggering over spontaneous LH rise. The other parameters influencing the results were the women’s age, the number of mature follicles obtained (≥2), the endometrial thickness (10–11 mm), and the number of progressive motile spermatozoa inseminated (>1 million).

Conclusion(s):

In women aged ≤38 years, IUI-H should be considered as an option, particularly in cases of female infertility from ovulation disorders, in cases of a normal ovarian reserve, in cases of secondary infertility, or when ≥1 million progressive sperm are inseminated. Bifollicular stimulation is required. In other cases, in vitro fertilization should be discussed as the first-line treatment.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)00039-9/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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