A multicenter prospective study to assess the effect of early cleavage on embryo quality implantation and live birth rate

The presence of early cleavage does not seem to improve implantation after the usual morphologic evaluation of cleavage-stage embryos.

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Maria J. de los Santos, Ph.D., Gemma Arroyo, Ph.D., Ana Busquet, Ph.D., Gloria Calderón, Ph.D., Jorge Cuadros, Ph.D., Maria Victoria Hurtado de Mendoza, Ph.D., Marta Moragas, Ph.D., Raquel Herrer, Ph.D., Agueda Ortiz, Ph.D., Carme Pons, Ph.D., Jorge Ten, Ph.D., Miguel Angel Vilches, Ph.D., Maria J. Figueroa, Ph.D.

Volume 101, Issue 4, Pages 981-987



To investigate the impact of early cleavage (EC) on embryo quality, implantation, and live-birth rates.


Prospective cross-sectional study.


Multicenter study.


Seven hundred embryo transfers and 1,028 early-stage human embryos.



Main Outcome Measure(s):

Implantation according to the presence of EC and embryo quality.


The presence of EC is associated with embryo quality, especially in cycles with autologous oocytes. However, the use of EC as an additional criterion for selecting an embryo for transfer does not appear to significantly improve likelihood of implantation. Furthermore, embryos that presented EC had live-birth rates per implanted embryo similar to those that did not show any sign of cleavage.


At least for conventional embryo culture and morphologic evaluations, the additional evaluation of EC in embryos may not be valuable to improve embryo implantation.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03479-1/fulltext

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.