Oocyte number as a predictor for ovarian hyperstimulation syndrome and live birth an analysis of 256381 in vitro fertilization cycles

The retrieval of >15 oocytes in fresh autologous IVF cycles significantly increases the risk of ovarian hyperstimulation syndrome without improving live-birth rate.

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Authors

Ryan G. Steward, M.D., Lan Lan, Ph.D., Anish A. Shah, M.D., M.H.S., Jason S. Yeh, M.D., Thomas M. Price, M.D., James M. Goldfarb, M.D., Suheil J. Muasher, M.D.

Volume 101, Issue 4, Pages 967-973

Abstract

Objective:

To investigate the association between oocyte number and the rates of ovarian hyperstimulation syndrome (OHSS) and live birth (LB) in fresh autologous in vitro fertilization (IVF) cycles.

Design:

Retrospective cohort study.

Setting:

An academic reproductive medicine practice.

Patient(s):

We analyzed data from 256,381 IVF cycles using the 2008–2010 Society for Assisted Reproductive Technology national registry. Patients were divided into five groups based on retrieved oocyte number.

Main Outcome Measure(s):

Rates of OHSS and LB were calculated for each group. A generalized estimating equation (GEE) was used to assess differences in OHSS and LB between groups. Receiver operating characteristic (ROC) curves were used to evaluate oocyte number as a predictor of OHSS and LB.

Intervention(s):

None.

Result(s):

The LB rate increased up to 15 oocytes, then plateaued (0–5: 17%, 6–10: 31.7%; 11–15: 39.3%; 16–20: 42.7%; 21–25: 43.8%; and >25 oocytes: 41.8%). However, the rate of OHSS became much more clinically significant after 15 oocytes (0–5: 0.09%; 6–10: 0.37%; 11–15: 0.93%; 16–20: 1.67%; 21–25: 3.03%; and >25 oocytes: 6.34%). These trends remained after adjustment with the use of GEE. ROC curves revealed that although oocyte number is not useful in the prediction of LB, 15 retrieved oocytes is the number that best predicts OHSS risk.

Conclusion(s):

Retrieval of >15 oocytes significantly increases OHSS risk without improving LB rate in fresh autologous IVF cycles. In general, less aggressive stimulation protocols should be considered, especially in high-responders, to optimize outcomes.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03458-4/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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