Yeon-Ah Sung, M.D., Hyejin Lee, M.D., Jee-Young Oh, M.D., Hyewon Chung, M.D.
Volume 101, Issue 3, Pages 840-845, March 2014
To determine the features of polycystic ovary syndrome (PCOS) that are implicated in the associated reproductive and metabolic morbidities.
Cross-sectional case–control study.
Academic medical setting.
A total of 1,062 women with PCOS and 1,887 women without PCOS.
Main Outcome Measure(s):
Physical examination including hirsutism scoring, biochemical and hormone measurements, ovarian ultrasound, and a 75-g oral glucose tolerance test to measure glucose and insulin levels.
A factor analysis identified four dominant factors in women with PCOS. These factors were interpreted as follows:  metabolic and hyperandrogenemia factor,  oligomenorrhea and hyperandrogenemia factor,  blood pressure factor, and  ovarian morphology factor. In women with PCOS, hyperandrogenemia was a significant predictor of metabolic syndrome after adjusting for age, body mass index, and insulin resistance in the regression analysis.
A factor analysis identified multiple factors that are responsible for the abnormalities associated with PCOS. Hyperandrogenemia was a common underlying feature of the metabolic and reproductive abnormalities in women with PCOS but not in women without PCOS.
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