Hyperandrogenemia is implicated in both the metabolic and reproductive morbidities of polycystic ovary syndrome

A factor analysis identified multiple factors that are responsible for the abnormalities associated with PCOS. Hyperandrogenemia was a common underlying feature of the metabolic and reproductive abnormalities in women with PCOS.

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Authors

Yeon-Ah Sung, M.D., Hyejin Lee, M.D., Jee-Young Oh, M.D., Hyewon Chung, M.D.

Volume 101, Issue 3, Pages 840-845, March 2014

Abstract

Objective:

To determine the features of polycystic ovary syndrome (PCOS) that are implicated in the associated reproductive and metabolic morbidities.

Design:

Cross-sectional case–control study.

Setting:

Academic medical setting.

Patient(s):

A total of 1,062 women with PCOS and 1,887 women without PCOS.

Intervention(s):

None.

Main Outcome Measure(s):

Physical examination including hirsutism scoring, biochemical and hormone measurements, ovarian ultrasound, and a 75-g oral glucose tolerance test to measure glucose and insulin levels.

Result(s):

A factor analysis identified four dominant factors in women with PCOS. These factors were interpreted as follows: [1] metabolic and hyperandrogenemia factor, [2] oligomenorrhea and hyperandrogenemia factor, [3] blood pressure factor, and [4] ovarian morphology factor. In women with PCOS, hyperandrogenemia was a significant predictor of metabolic syndrome after adjusting for age, body mass index, and insulin resistance in the regression analysis.

Conclusion(s):

A factor analysis identified multiple factors that are responsible for the abnormalities associated with PCOS. Hyperandrogenemia was a common underlying feature of the metabolic and reproductive abnormalities in women with PCOS but not in women without PCOS.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03287-1/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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