Hyperandrogenemia is implicated in both the metabolic and reproductive morbidities of polycystic ovary syndrome

A factor analysis identified multiple factors that are responsible for the abnormalities associated with PCOS. Hyperandrogenemia was a common underlying feature of the metabolic and reproductive abnormalities in women with PCOS.

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Authors

Yeon-Ah Sung, M.D., Hyejin Lee, M.D., Jee-Young Oh, M.D., Hyewon Chung, M.D.

Volume 101, Issue 3, Pages 840-845, March 2014

Abstract

Objective:

To determine the features of polycystic ovary syndrome (PCOS) that are implicated in the associated reproductive and metabolic morbidities.

Design:

Cross-sectional case–control study.

Setting:

Academic medical setting.

Patient(s):

A total of 1,062 women with PCOS and 1,887 women without PCOS.

Intervention(s):

None.

Main Outcome Measure(s):

Physical examination including hirsutism scoring, biochemical and hormone measurements, ovarian ultrasound, and a 75-g oral glucose tolerance test to measure glucose and insulin levels.

Result(s):

A factor analysis identified four dominant factors in women with PCOS. These factors were interpreted as follows: [1] metabolic and hyperandrogenemia factor, [2] oligomenorrhea and hyperandrogenemia factor, [3] blood pressure factor, and [4] ovarian morphology factor. In women with PCOS, hyperandrogenemia was a significant predictor of metabolic syndrome after adjusting for age, body mass index, and insulin resistance in the regression analysis.

Conclusion(s):

A factor analysis identified multiple factors that are responsible for the abnormalities associated with PCOS. Hyperandrogenemia was a common underlying feature of the metabolic and reproductive abnormalities in women with PCOS but not in women without PCOS.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03287-1/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.