Association of five common polymorphisms in the plasminogen activator inhibitor 1 gene with primary ovarian insufficiency

PAI-1 9785GA+AA, 844A/9785A, 4G/9785A, and 9785A/11053Gmay contribute to prevalence of primary ovarian insufficiency (POI) in Korean women.

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Authors

Nam Keun Kim, Ph.D., Young Joo Jeon, M.S., Young Ran Kim, M.D., Bo Eun Lee, M.S., Sun Hee Cha, M.D., Ph.D., Doyeun Oh, M.D., Ph.D., Woo Sik Lee, M.D., Ph.D., Myoung-Jin Moon, M.D., Ph.D.

Volume 101, Issue 3, Pages 825-832.e1, March 2014

Abstract

Objective:

To investigate the association between potentially functional plasminogen activator inhibitor-1 (PAI-1) genetic polymorphisms and primary ovarian insufficiency (POI).

Design:

Case–control study.

Setting:

Urban university-based hospital.

Patient(s):

A cohort of 137 POI patients and 227 controls.

Intervention(s):

None.

Main Outcome Measure(s):

Genotyping of five PAI-1 polymorphisms (−844G>A [rs2227631], −675 4G/5G [rs1799889], 43G>A (Ala>Thr) [rs6092], 9785G>A [rs2227694], and 11053T>G [rs7242]) was assessed by polymerase chain reaction–restriction fragment length polymorphism assay.

Result(s):

PAI-1 polymorphisms 9785GA+AA, −844A/9785A, 4G/9785A, and 9785A/11053G were associated with POI occurrence. Moreover, −844GA+AA and 11053TG+GG were associated with lower serum E2 levels in controls.

Conclusion(s):

We have identified an association between five PAI-1 polymorphisms and POI occurrence. However, the mechanism underlying the function of these polymorphisms in POI remains to be determined. Further studies are needed to improve understanding of the roles of PAI-1 polymorphisms and genes in related pathways, using a larger and more heterogeneous cohort.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03268-8/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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