Outcomes of operative sperm retrieval strategies for fertility preservation among males scheduled to undergo cancer treatment

Electroejaculation and testicular sperm extraction led to successful sperm retrieval in 60% of adolescents and teenagers and 59% of adult men seeking fertility preservation before cancer therapy.

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Authors

Boback M. Berookhim, M.D., M.B.A., John P. Mulhall, M.D., M.Sc., F.E.C.S.M.

Volume 101, Issue 3, Pages 805-811, March 2014

Abstract

Objective:

To describe the outcomes of electroejaculation (EEJ) and testicular sperm extraction (TESE) performed for fertility preservation among male patients who are unable to ejaculate or have nonobstructive azoospermia/severe oligospermia before definitive cancer therapy.

Design:

Retrospective cohort study.

Setting:

Tertiary cancer referral center.

Patient(s):

Forty-nine patients seeking fertility preservation before definitive cancer therapy, with anejaculation, religious or cultural objections to masturbation, azoospermia, or severe oligospermia requiring either EEJ or TESE.

Intervention(s):

EEJ and TESE.

Main Outcome Measure(s):

Sperm retrieval rates.

Result(s):

Fifty-nine percent of patients overall and 60% of adolescents/young adults had sperm retrieved for cryopreservation. EEJ was successful in retrieving sperm in 60% of adolescents. Of all adolescents and young adults undergoing TESE, 33% had sperm retrieved for cryopreservation. No complications were reported. Chemotherapy was commenced without delay in all patients requiring it, frequently on the same day as the sperm retrieval.

Conclusion(s):

EEJ and TESE can be safely and successfully used for fertility preservation before cancer therapy among boys and young adult men who are unable to provide a semen specimen or have nonobstructive azoospermia, and they should be considered in all men meeting this patient profile.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03382-7/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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