Authors

Renato Polimanti, Ph.D., Maria Eleonora Graziano, M.Sc., Natalia Lazzarin, M.D., Ph.D., Elena Vaquero, M.D., Dario Manfellotto, M.D., Maria Fuciarelli, Ph.D.

Volume 101, Issue 3, Pages 735-739, March 2014

Abstract

Objective:

To explore the role of the GSTO1 gene in the pathogenesis of recurrent miscarriage (RM).

Design:

Genetic association study.

Setting:

Rome, Italy.

Patient(s):

123 women with RM and 130 women without pregnancy complications.

Intervention(s):

None.

Main Outcome Measure(s):

Genotyping of two single nucleotide polymorphisms (A140D and E208K) and a 3-bp deletion (E155del) of the GSTO1 gene.

Result(s):

We found a statistically significant association between GSTO1*E208K variants and RM risk. Specifically, we identified this uncommon genetic variant only in women with RM. None of the women with physiologic pregnancies were carriers of K208 allele.

Conclusion(s):

GSTO1 has a role in detoxification metabolism, and we hypothesize that a functional variation of GSTO1 is a RM risk factor that interacts with environmental conditions.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03429-8/fulltext