Unilateral oophorectomy results in compensatory follicular recruitment in the remaining ovary at time of ovarian stimulation for in vitro fertilization

Women with a prior unilateral oophorectomy have compensatory follicular recruitment in the remaining ovary, and right ovaries respond better than left ovaries after stimulation for IVF.

Like Comment

Authors

Zaraq Khan, M.B.B.S., Ravi P. Gada, M.D., Zaid M. Tabba, M.D., Shannon K. Laughlin-Tommaso, M.D., Jani R. Jensen, M.D., Charles C. Coddington, M.D., Elizabeth A. Stewart, M.D.

Volume 101, Issue 3, Pages 722-727, March 2014

Abstract

Objective:

To assess the effect of unilateral oophorectomy (UO) by assessing ovarian reserve (OVR) and the response to gonadotropin stimulation in women with UO undergoing in vitro fertilization (IVF) compared with the response of the ipsilateral ovary of women without UO.

Design:

Historical cohort study.

Setting:

Academic fertility clinic.

Patient(s):

Fifty-one women with single ovary compared with a referent group with both ovaries in a 1:2 fashion.

Intervention(s):

None.

Main Outcome Measure(s):

Day-3 follicle-stimulating hormone (FSH), estradiol, and antral follicle counts as measures of OVR, and IVF outcomes including number of follicles aspirated and oocytes retrieved.

Result(s):

The baseline demographics and serum markers of OVR were not different. Referent women had greater follicular yield and oocyte numbers when compared with women with UO; however, when compared with the ipsilateral ovary of the referents, women with UO had a higher antral follicle count and greater follicle and oocyte numbers. In multivariate analyses, the ovary from women with UO was more likely to yield more than the median number of follicles and oocytes than the ipsilateral ovary in referent women. Live-birth rates in both groups were similar.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03279-2/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.