Effect of fibroids not distorting the endometrial cavity on the outcome of in vitro fertilization treatment A retrospective cohort study

A retrospective cohort study demonstrates that intramural fibroids with diameter larger than 2.85 cm have a negative effect on in vitro fertilization/intracytoplasmic sperm injection delivery rates.

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Lei Yan, M.D., Lingling Ding, M.D., Chunyan Li, M.D., Yu Wang, Rong Tang, M.D., Ph.D., Zi-Jiang Chen, M.D.Ph.D.

Volume 101, Issue 3, Pages 716-721.e6, March 2014



To investigate the effect of fibroids that do not distort the endometrial cavity on IVF/intracytoplasmic sperm injection (ICSI) outcomes and to identify certain fibroid subgroups that may be deleterious to fertility outcomes.


Retrospective cohort study.


University-based reproductive medicine center.


A total of 10,268 patients undergoing IVF/ICSI between 2009 and 2011 in our unit.


Transvaginal ultrasound and hysteroscopy; controlled ovarian hyperstimulation and IVF/ICSI; strict matching criteria.

Main Outcome Measure(s):

Cycle cancellation, clinical pregnancy, miscarriage, and delivery rates.


We included 249 patients with fibroids who underwent IVF/ICSI. Higher day 3 FSH levels were found in women with fibroids compared with in control subjects. No significant differences were found in IVF/ICSI outcomes between the two groups. Patients with intramural fibroids with the largest diameter


Our results suggest that although non-cavity-distorting fibroids do not affect IVF/ICSI outcomes, intramural fibroids greater than 2.85 cm in size significantly impair the delivery rate of patients undergoing IVF/ICSI.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03283-4/fulltext

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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