Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short antagonist protocol A prospective cohort study

Progesterone (P) level at oocyte retrieval was inversely associated with pregnancy rates: as P levels increased, pregnancy rates decreased. The odds ratio for nonpregnancy was clinically significant when P was 12 ng/mL.

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Shweta Nayak, M.D., Melanie E. Ochalski, M.D., Bo Fu, Ph.D., Kathryn-Mary Wakim, TianJao Chu, Ph.D., Xinxin Dong, Ph.D., Anthony N. Wakim, M.D.

Volume 101, Issue 3, Pages 676-682.e1, March 2014



To evaluate the distribution of P levels on the day of oocyte retrieval as it relates to pregnancy outcome in an antagonist protocol, which may be at higher risk for elevated P levels.


Prospective cohort study.


Academic IVF center.


One hundred eighty-six women undergoing controlled ovarian hyperstimulation with an antagonist protocol.



Main Outcome Measure(s):

Implantation, pregnancy, and spontaneous abortion rates were collected.


Implantation rate (positive hCG 14 days after ET) and pregnancy rate were significantly higher when the P level was


Elevated P on the day of oocyte retrieval is associated with significantly lower implantation and ongoing pregnancy rates. This is the first study to date to both uncover the distribution of P on the day of oocyte retrieval in an antagonist cycle and determine the impact an elevation may have on pregnancy outcome.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.