Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short antagonist protocol A prospective cohort study

Progesterone (P) level at oocyte retrieval was inversely associated with pregnancy rates: as P levels increased, pregnancy rates decreased. The odds ratio for nonpregnancy was clinically significant when P was 12 ng/mL.

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Shweta Nayak, M.D., Melanie E. Ochalski, M.D., Bo Fu, Ph.D., Kathryn-Mary Wakim, TianJao Chu, Ph.D., Xinxin Dong, Ph.D., Anthony N. Wakim, M.D.

Volume 101, Issue 3, Pages 676-682.e1, March 2014



To evaluate the distribution of P levels on the day of oocyte retrieval as it relates to pregnancy outcome in an antagonist protocol, which may be at higher risk for elevated P levels.


Prospective cohort study.


Academic IVF center.


One hundred eighty-six women undergoing controlled ovarian hyperstimulation with an antagonist protocol.



Main Outcome Measure(s):

Implantation, pregnancy, and spontaneous abortion rates were collected.


Implantation rate (positive hCG 14 days after ET) and pregnancy rate were significantly higher when the P level was


Elevated P on the day of oocyte retrieval is associated with significantly lower implantation and ongoing pregnancy rates. This is the first study to date to both uncover the distribution of P on the day of oocyte retrieval in an antagonist cycle and determine the impact an elevation may have on pregnancy outcome.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.