Age does not adversely affect sperm retrieval in men undergoing microdissection testicular sperm extraction

Sperm retrieval in men undergoing microdissection testicular sperm extraction (micro-TESE) was not negatively affected by age. Men 50 years old who underwent successful micro-TESE were more likely to have larger testes.

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Authors

Ranjith Ramasamy, M.D., Nikunj N. Trivedi, B.S., Jennifer E. Reifsnyder, M.D., Gianpiero D. Palermo, M.D., Ph.D., Zev Rosenwaks, M.D., Peter N. Schlegel, M.D.

Volume 101, Issue 3, Pages 653-655, March 2014

Abstract

Objective:

To evaluate the effect of male age on the outcome of microdissection testicular sperm extraction (micro-TESE) and assisted reproductive technology.

Design:

Clinical retrospective study.

Setting:

Center for reproductive medicine at a tertiary university hospital.

Patient(s):

One thousand sixty-seven men with nonobstructive azoospermia.

Intervention(s):

Micro-TESE, with intracytoplasmic sperm injection when sperm found.

Main Outcome Measure(s):

Sperm retrieval and clinical pregnancy.

Result(s):

Sperm were successfully retrieved by micro-TESE in 605 men (56.6%) overall. Sperm retrieval rates (SRRs) were higher in men ≥50 years old than men <50, (73% in men ≥50, 56% in men <50). Of the 44 men ≥50 years old, men who had successful micro-TESE had larger mean testis volume (20.8 cc vs. 12.5 cc), a higher frequency of hypospermatogenesis (5.6% vs. 0%), and a lower frequency of Sertoli cells only (12.5% vs. 80%) on diagnostic biopsy. Clinical pregnancy rates were lower in partners of men ≥50 than in partners of men

Conclusion(s):

Overall, SRRs in men undergoing micro-TESE are not negatively affected by age. Despite successful sperm retrieval in older men with micro-TESE, couples have the best chance of clinical pregnancy with a female partner

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03383-9/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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