Influence of vitamin D levels on in vitro fertilization outcomes in donor recipient cycles

In this retrospective cohort study, we measured vitamin D levels in 99 recipients of egg donation. Nonreplete vitamin D status [25(OH)D<30 ng/mL] was associated with lower clinical pregnancy and live-birth rates.

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Authors

Briana J. Rudick, M.D., Sue Ingles, Ph.D., Karine Chung, M.D., M.S.C.E., Frank Z. Stanczyk, Ph.D., Richard Paulson, M.D., Kristin Bendikson, M.D.

Volume 101, Issue 2, Pages 447-452, February 2014

Abstract

Objective:

To elucidate the role of vitamin D in reproduction by examining the relationship between recipient vitamin D levels and pregnancy rates in donor-recipient IVF cycles.

Design:

Retrospective cohort study.

Setting:

Academic tertiary care center.

Patient(s):

Ninety-nine recipients of egg donation at University of Southern California Fertility.

Intervention(s):

Serum was collected from egg donor recipients before ET and was tested for vitamin D levels [25(OH)D].

Main Outcome Measure(s):

Clinical pregnancy as defined by sonographic presence of a heartbeat at 7–8 weeks of gestation.

Result(s):

In a diverse population of 99 recipients (53% Caucasian, 20% Asian, 16% Hispanic, 7% African American), adjusted clinical pregnancy rates were lower among vitamin D–deficient recipients than among vitamin D–replete recipients (37% vs. 78%). Live-birth rates were 31% among vitamin D–deficient recipients, compared with 59% among vitamin D–replete recipients. There were no differences in adjusted clinical pregnancy and live-birth rates among recipients who were vitamin D deficient [25(OH)D<20 ng/mL] vs. among those who were vitamin D insufficient [20 ng/mL ≤ 25(OH)D<30 ng/mL]. Conclusion(s):

Nonreplete vitamin D status [25(OH)D<30 ng/mL] was associated with lower pregnancy rates in recipients of egg donation. Since the oocyte donor-recipient model is able to separate the impact of vitamin D on oocyte vs. endometrium, these data suggest that the effects of vitamin D may be mediated through the endometrium.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03154-3/fulltext


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Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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