Healthy live birth using theophylline in a case of retrograde ejaculation and absolute asthenozoospermia

Theophylline was an efficient tool in stimulating immotile spermatozoa in patients with retrograde ejaculation.

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Authors

Ebner Thomas, Ph.D., Shebl Omar, M.D., Mayer Richard Bernhard, M.D., Moser Marianne, Ph.D., Costamoling Walter, M.D., Oppelt Peter, M.D.

Volume 101, Issue 2, Pages 340-343, February 2014

Abstract

Objective:

To analyze whether the use of ready-to-use theophylline is a feasible option in a case of retrograde ejaculation and absolute asthenozoospermia.

Design:

Case report.

Setting:

In vitro fertilization unit of a public hospital.

Patient(s):

Thirty-one-year-old nulliparous woman, and 39-year-old male with retrograde ejaculation and absolute asthenozoospermia.

Intervention(s):

Retrieval of postejaculatory urine, restoration of motility using a methylxanthine, intracytoplasmic sperm injection, single-embryo transfer.

Main Outcome Measure(s):

Sperm motility, fertilization, embryo quality, live birth.

Result(s):

Successful fertilization and a single-embryo transfer resulted in a healthy live birth.

Conclusion(s):

Theophylline turned out to be a safe, efficient agent for stimulating immotile spermatozoa in patients with retrograde ejaculation.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03123-3/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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