Fertility in patients with congenital adrenal hyperplasia

Given the relevance of congenital adrenal hyperplasia (CAH) in reproductive medicine, we review the reproductive pathophysiology of both classic and nonclassic CAH and present contemporary treatment options.

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David E. Reichman, M.D., Perrin C. White, M.D., Maria I. New, M.D., Zev Rosenwaks, M.D.

Volume 101, Issue 2, Pages 301-309, February 2014


Congenital adrenal hyperplasia (CAH) is the most frequently encountered genetic steroid disorder affecting fertility. Steroid hormones play a crucial role in sexual development and reproductive function; patients with either 21- hydroxylase or 11β-hydroxylase deficiency thus face immense challenges to their fertility. Given the relevance of CAH in reproductive medicine as well as the diagnostic challenges posed by the phenotypic overlap with polycystic ovary syndrome, we review the reproductive pahophysiology of both classic and nonclassic CAH and present contemporary treatment options.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03255-X/fulltext

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.