Decreased inhibin B responses following recombinant human chorionic gonadotropin administration in normal women and women with polycystic ovary syndrome

In normal and polycystic ovary syndrome (PCOS) women, inhibin B production was decreased following recombinant hCG administration. These findings suggest that in PCOS women, androgen excess is not enhanced by LH-stimulated inhibin B production.

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Authors

Rana F. Shayya, M.D., Marcus A. Rosencrantz, M.D., Sandy S. Chuan, M.D., Heidi Cook-Andersen, M.D., Ph.D., William E. Roudebush, Ph.D., H. I. Su, M.D., M.S.E.C., Shunichi Shimasaki, Ph.D., R. J. Chang, M.D.

Volume 101, Issue 1, Pages 275-279, January 2014

Abstract

Objective:

To determine whether granulosa cells contribute to excess androgen production, by assessing inhibin B (Inh B) responses to hCG in women with polycystic ovary syndrome (PCOS) and in normal women.

Design:

Prospective study.

Setting:

Academic medical center.

Patient(s):

Twenty women with PCOS and 16 normal women.

Intervention(s):

Blood samples obtained before and 24 hours after injection of 25 μg recombinant hCG (r-hCG).

Main Outcome Measure(s):

Basal and stimulated Inh B, E2, androstenedione (A), and T responses after r-hCG administration.

Result(s):

In normal and PCOS women, r-hCG induced a significant reduction of Inh B levels. Lowered Inh B responses were not related to body mass index, PCOS status, or age by multivariate regression. Recombinant hCG significantly increased serum A and E2 in both normal and PCOS women.

Conclusion(s):

In normal and PCOS women, Inh B production was decreased following r-hCG administration. These findings strongly suggest that in PCOS women androgen excess is not enhanced by LH-stimulated Inh B production.

Clinical Trial Registration Number:

NCT00747617.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)03111-7/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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