Association of blood type and patient characteristics with ovarian reserve

No relationship could be demonstrated between blood type and risk of diminished ovarian reserve in an analysis of 305 patients undertaking in vitro fertilization.


Kathryn S. Timberlake, Kristie L. Foley, Ph.D., Bradley S. Hurst, M.D., Michelle L. Matthews, M.D., Rebecca S. Usadi, M.D., Paul B. Marshburn, M.D., Paul Marshburn, M.D.

Volume 100, Issue 6, Pages 1735-1739, December 2013



To assess whether blood type was associated with diminished ovarian reserve (DOR) (day-3 follicle-stimulating hormone level >10 IU/L), controlling for history of tobacco smoking, body mass index (BMI), history of endometriosis, ovarian surgery, previous pregnancy, and maternal age.


Cross-sectional study.


Academic medical center, Division of Reproductive Endocrinology and Infertility.


Women undergoing in vitro fertilization (IVF) from 2006–2011 (n = 305).



Main Outcome Measure(s):

Presence of DOR in relation to a patient’s blood type.


Other investigators have reported an increased risk for DOR in patients with blood type O and a protective effect on ovarian reserve for blood type A. We observed no association between a woman’s blood type and DOR. We found an increased risk for DOR in patients aged 35 and older. Obesity (BMI ≥30 vs. BMI <25) was associated with lower odds of DOR. Conclusion(s):

In comparison with blood type A, blood type O is not associated with an increase in DOR. We found no clinical implications for using blood type as a risk factor for DOR.

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