Peripheral natural killer cell activity as a predictor of recurrent pregnancy loss a large cohort study

Elevated peripheral blood NK cell activity was found to not be an independent risk factor for subsequent miscarriage.

Like Comment

Authors

Kinue Katano, M.D., Sadao Suzuki, M.D., Yasuhiko Ozaki, M.D., Nobuhiro Suzumori, M.D., Tamao Kitaori, M.D., Mayumi Sugiura-Ogasawara, M.D.

Volume 100, Issue 6, Pages 1629-1634, December 2013

Abstract

Objective:

To determine the predictive value of preconceptional peripheral blood natural killer (pNK) cell activity in patients with recurrent pregnancy loss (RPL).

Design:

Cohort study.

Setting:

University department.

Patient(s):

A total of 552 patients with a history of two to six consecutive miscarriages.

Intervention(s):

None.

Main Outcome Measure(s):

The predictive value of preconceptional pNK cell activity for subsequent miscarriage was analyzed using multivariable logistic regression analysis, with age, number of previous miscarriages, and presence/absence of previous live births and bed rest as covariates.

Result(s):

Age and number of previous miscarriages, but not high pNK cell activity, were found to be independent risk factors for a subsequent miscarriage. No effect of bed rest and previous live birth on the likelihood of live birth was observed (odds ratios 1.28 [95% confidence interval 0.81–2.02] and 0.91 [0.52–1.59], respectively).

Conclusion(s):

Elevated pNK cell activity was found to not be an independent risk factor for subsequent miscarriage. Clinicians should not measure the plasma NK activity as a systematic recurrent pregnancy loss examination, because its clinical significance is yet to be established.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)02782-9/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.