Normal live births after intracytoplasmic sperm injection in a man with the rare condition of Eagle Barrett syndrome prune belly syndrome

Intracytoplasmic sperm injection (ICSI) with sperm from a man with Eagle-Barrett syndrome (EBS) resulted in the births of two normal healthy male infants, suggesting that EBS is not transmitted to male offspring.


Steven Denis Fleming, Ph.D., Elizabeth Varughese, M.D., Vi-Khiem Hua, Ph.D., Amanda Robertson, B.Sc., Fiona J. Dalzell, M.D., Clare V. Boothroyd, M.D.

Volume 100, Issue 6, Pages 1532-1535, December 2013



To report the first live births of male infants resulting from intracytoplasmic sperm injection (ICSI) using spermatozoa from a man with Eagle-Barrett syndrome (EBS).


Case report.


Assisted conception unit within a private hospital.


An infertile couple.


An infertile couple received repeated treatment with ICSI.

Main Outcome Measure(s):

Clinical pregnancy and a normal live birth.


In 2008, after microinjection of ten oocytes, the transfer of a single expanded blastocyst led to the premature birth of a morphologically normal male infant at 18 weeks’ gestation. This outcome followed preterm rupture of membranes and possible cervical incompetence. In 2009, after microinjection of six oocytes, transfer of a single 5-cell embryo led to a singleton pregnancy, with emergency cervical cerclage being performed at 21 weeks. A healthy male infant was born at 30 weeks, with no evidence of EBS, by lower-segment cesarean section for breech presentation and premature labor. In 2012, after elective laparoscopic placement of cervical suture, microinjection of ten oocytes and transfer of a single 4-cell embryo led to a singleton pregnancy with a healthy male infant, with no evidence of EBS, being born by cesarean section at 38 weeks.


This report suggests that EBS is not transmitted to male offspring via ICSI.

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