Normal live births after intracytoplasmic sperm injection in a man with the rare condition of Eagle Barrett syndrome prune belly syndrome

Intracytoplasmic sperm injection (ICSI) with sperm from a man with Eagle-Barrett syndrome (EBS) resulted in the births of two normal healthy male infants, suggesting that EBS is not transmitted to male offspring.

Like Comment

Authors

Steven Denis Fleming, Ph.D., Elizabeth Varughese, M.D., Vi-Khiem Hua, Ph.D., Amanda Robertson, B.Sc., Fiona J. Dalzell, M.D., Clare V. Boothroyd, M.D.

Volume 100, Issue 6, Pages 1532-1535, December 2013

Abstract

Objective:

To report the first live births of male infants resulting from intracytoplasmic sperm injection (ICSI) using spermatozoa from a man with Eagle-Barrett syndrome (EBS).

Design:

Case report.

Setting:

Assisted conception unit within a private hospital.

Patient(s):

An infertile couple.

Interventions:

An infertile couple received repeated treatment with ICSI.

Main Outcome Measure(s):

Clinical pregnancy and a normal live birth.

Result(s):

In 2008, after microinjection of ten oocytes, the transfer of a single expanded blastocyst led to the premature birth of a morphologically normal male infant at 18 weeks’ gestation. This outcome followed preterm rupture of membranes and possible cervical incompetence. In 2009, after microinjection of six oocytes, transfer of a single 5-cell embryo led to a singleton pregnancy, with emergency cervical cerclage being performed at 21 weeks. A healthy male infant was born at 30 weeks, with no evidence of EBS, by lower-segment cesarean section for breech presentation and premature labor. In 2012, after elective laparoscopic placement of cervical suture, microinjection of ten oocytes and transfer of a single 4-cell embryo led to a singleton pregnancy with a healthy male infant, with no evidence of EBS, being born by cesarean section at 38 weeks.

Conclusion(s):

This report suggests that EBS is not transmitted to male offspring via ICSI.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)02780-5/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.