Effect of single dose methotrexate on ovarian reserve in women with ectopic pregnancy

We studied the effect of single-dose systemic methotrexate treatment on ovarian reserve in ectopic pregnancy and concluded that methotrexate treatment has no effect on short-term ovarian reserve.

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Ibrahim Uyar, M.Da., Onur Umut Yucel, M.Da., Cenk Gezer, M.Da., Ibrahim Gulhan, M.Da., Buket Karis, M.Da., H. Merih Hanhan, M.Da., Mehmet Ozeren, M.D.

Volume 100, Issue 5, Pages 1310-1313, November 2013



To evaluate ovarian reserve in women with ectopic pregnancy treated with single-dose systemic methotrexate in the early post-treatment period.


Prospective study.


Women’s health education and research hospital.

Patient (s):

Eighty-two patients with ectopic pregnancy and 80 healthy women in the same age group were included in the study. Of the 82 patients, 49 with ectopic pregnancy were treated with single-dose systemic methotrexate (MTX) and 33 were treated surgically with laparoscopy or laparotomy (salpingectomy or salpingostomy).


Ovarian reserve testing.

Main Outcome Measure(s):

Basal FSH on the 3rd day of the menstrual cycle, E2, basal antral follicle count (AFC), and ovarian volume.


There were no differences among the groups in terms of basal FSH, E2, AFC, and ovarian volume.


The single-dose MTX treatment had no effect on ovarian reserve in women with ectopic pregnancy as measured by the above-mentioned parameters.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00740-1/fulltext

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.