Does culture medium influence offspring birth weight

After analyzing the influence of different embryo culture media on the weight of the newborn, the results do not show any relationship between them.

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Authors

Beatriz Carrasco, M.Sc., Montserrat Boada, Ph.D., Ignacio Rodríguez, B.Sc., Buenaventura Coroleu, M.D., Ph.D., Pedro N. Barri, M.D.,Ph.D., Anna Veiga, Ph.D.

Volume 100, Issue 5, Pages 1283-1288, November 2013

Abstract

Objective:

To determine whether the type of medium used to culture human embryos in vitro influences neonatal birth weight after IVF/intracytoplasmic sperm injection (ICSI).

Design:

A prospective study and a retrospective study.

Setting:

Private assisted reproduction center.

Patient(s):

The prospective study included 449 IVF/ICSI cycles from August to December 2008. The retrospective analysis was performed for 2,518 IVF/ICSI cycles from October 2006 to December 2010.

Intervention(s):

In the prospective study, patients were randomized for embryo culture in Cook or Vitrolife medium. The retrospective study was performed with three different culture media (MediCult, Cook, and Vitrolife).

Main Outcome Measure(s):

Mean birth weight, adjusted for gestational age and gender (z score) of newborns.

Result(s):

In the prospective study, the average z score was −0.19 ± 0.85 in Cook and 0.08 ± 1.40 in Vitrolife. In the retrospective study, the z scores obtained in each group were as follows: Cook, −0.14 ± 0.96; MediCult, 0.06 ± 1.13; and Vitrolife, 0.03 ± 1.05. No significant differences were observed regarding the birth weight of children born in the different groups in both studies.

Conclusion(s):

The results do not show any relationship between the medium used for in vitro culture and mean birth weight adjusted for gestational age and gender of singletons born after IVF/ICSI.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00756-5/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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