Obesity reduces uterine receptivity clinical experience from 9587 first cycles of ovum donation with normal weight donors

Female obesity impairs the reproductive outcome of ovum donation by reducing uterine receptivity.

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Authors

José Bellver, M.D., Antonio Pellicer, M.D., Juan Antonio García-Velasco, M.D., Agustín Ballesteros, M.D., José Remohí, M.D., Marcos Meseguer, Ph.D.

Volume 100, Issue 4, Pages 1050-1058.e2, October 2013

Abstract

Objective:

To analyze the reproductive outcome of recipients of donated ova according to their body mass index (BMI).

Design:

Twelve-year retrospective cohort analysis.

Setting:

Fertility clinics.

Patient(s):

9,587 first cycles of ovum donation with ova from normoweight donors.

Intervention(s):

Recipients divided according to their BMI to analyze IVF laboratory and outcome parameters: lean with BMI <20 kg/m2 (n = 1,458; 15.2%); normoweight with BMI 20–24.9 kg/m2 (n = 5,706; 59.5%), overweight with BMI 25–29.9 kg/m2 (n = 1,770; 18.5%), and obese with BMI ≥30 kg/m2 (n = 653; 6.8%). Main Outcome Measure(s):

Implantation, biochemical and clinical pregnancy, miscarriage, and live-birth rates.

Result(s):

In vitro fertilization laboratory parameters did not differ according to BMI. However, implantation, pregnancy, clinical pregnancy, twin pregnancy, and live-birth rates were significantly reduced as BMI increased. In the lean, normoweight, overweight, and obese groups, the implantation rate was 40.4%, 39.9%, 38.5%, and 30.9%, clinical pregnancy rate was 56.9%, 55.9%, 54.3%, and 45.3%, and live-birth rate was 38.6%, 37.9%, 34.9%, and 27.7%, respectively. However, clinical miscarriage rates were similar in all the groups.

Conclusion(s):

Female obesity impairs the reproductive outcome of ovum donation probably as a result of reduced uterine receptivity.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00695-X/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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