Unexplained pregnancy loss a marker of basal endothelial dysfunction

We found significantly lower platelet and higher endothelial circulating microparticles in 124 women with previous unexplained pregnancy loss compared with 273 healthy parous controls.

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Authors

Elisabeth Pasquier, Ph.D., M.D., Luc De Saint Martin, Ph.D., M.D., Caroline Bohec, M.D., Michel Collet, Ph.D., M.D., Françoise Dignat-George, Ph.D., M.D., Dominique Mottier, Ph.D., M.D.

Volume 100, Issue 4, Pages 1013-1017, October 2013

Abstract

Objective:

To compare the microparticle levels of women referred for unexplained pregnancy loss with those of parous controls.

Design:

Incident case-control study.

Setting:

University medical center.

Patient(s):

124 women consecutively referred for unexplained pregnancy losses (two or more losses at or before 21 weeks of gestational age, or at least one later loss), and 273 parous women without pregnancy loss.

Intervention(s):

Numeration of circulating microparticles by flow cytometry after differentiation of subpopulations according to the expression of membrane-specific antigens (CD51, CD144, or CD146 for endothelial, CD41 for platelet, CD45 and CD66b for leukocyte and neutrophil microparticles).

Main Outcome Measure(s):

Plasma levels of microparticles.

Results:

A relative hypercoagulable state assessed by thrombin generation test had been previously reported in such cases, so we hypothesized that this could be explained by an excess of procoagulant microparticles. The study women displayed statistically significantly lower platelet and higher endothelial microparticle levels than the controls. The parameters of the thrombin generation test were only correlated with the level of endothelial microparticles, with a low coefficient of Speerman’s correlation (r=0.15).

Conclusion(s):

The difference in microparticle levels between the patients and controls does not clearly explain the hypercoagulable state reported in the patients but could reflect chronic endothelium damage.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00702-4/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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