Antimüllerian hormone as predictor of reproductive outcome in subfertile women with elevated basal follicle-stimulating hormone levels: a follow-up study

In a prospective cohort study in subfertile women with elevated basal FSH levels, AMH is identified as a marker for actual fertility.
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Authors

Felicia Yarde, M.D., Marlies Voorhuis, M.D., Madeleine Dólleman, M.D., Erik A.H. Knauff, M.D., Ph.D., Marinus J.C. Eijkemans, M.Sc., Frank J.M. Broekmans, M.D., Ph.D.

Volume 100, Issue 3, Pages 831-838.e2, September 2013

Abstract

Objective:

To investigate the role of serum antimüllerian hormone (AMH) as a predictor of live birth and reproductive stage in subfertile women with elevated basal FSH levels.

Design:

A prospective observational cohort study conducted between February 2005 and June 2009.

Setting:

Tertiary fertility center.

Patient(s):

Subfertile women with [1] a regular menstrual cycle (mean cycle length 25–35 days); [2] basal FSH concentrations ≥12.3 IU/L; and [3] younger than 40 years (n = 96).

Intervention(s):

None.

Main Outcome Measure(s):

Live birth and reproductive stage according to the Stages of Reproductive Aging Workshop.

Result(s):

A cumulative live birth rate of 63.5% was observed during a median follow-up of 3.3 years (n = 85). The AMH level was significantly associated with live birth. There was evidence of a nonlinear prediction pattern, with an increase in chances of live birth until an AMH level of 1 μg/L. Other ovarian reserve tests and chronological age appeared of limited value in predicting live birth. In addition, AMH was significantly associated with the timing of reproductive stages (n = 68) (i.e., the occurrence of menopausal transition or menopause during follow-up).

Conclusion(s):

The present findings suggest applicability of AMH determination as a marker for actual fertility in subfertile women with elevated basal FSH levels.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00607-9/fulltext


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