Evaluation of diagnostic testis biopsy and the repetition of testicular sperm extraction surgeries in infertility patients

Testicular sperm extraction (TESE) should be considered regardless of the expected testicular histopathology. The chance of finding sperm by TESE decreases with each successive TESE procedure.

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Alayman Fathy Hussein, M.B.B.C.H., M.Sc., M.D.

Volume 100, Issue 1, Pages 88-93, July 2013



To evaluate the use of a diagnostic testis biopsy and a repetition of testicular sperm extraction (TESE) surgeries in azoospermic patients and its impact on the outcome of TESE.


Retrospective, case–control study.


University IVF center and hospital.


A total of 552 azoospermic patients undergoing TESE for intracytoplasmic injection.


At the time of the TESE, a piece of testicular tissue was prepared for histopathologic evaluation.

Main Outcome Measure(s):

Sperm retrieval rate.


Testicular sperm retrieval was successful in 100% of patients with obstructive azoospermia, 95.6% of patients with hypospermatogenesis, 47.9% of patients with maturation arrest, and 28.6% of patients with Sertoli cell–only syndrome in cases with no previous testicular surgery; in 100%, 91.4%, 32%, and 13.3%, respectively, in cases with a history of one testicular surgery; and in 100%, 10%, 0, and 0, respectively, in cases with a history of two testicular surgeries.


Testicular sperm retrieval may be successful for some patients in each histopathologic category of azoospermia, with variable degrees of success for different histopathologic categories. The repetition of testicular surgeries decreases the chance of finding sperm in subsequent testicular sperm retrieval procedures.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00423-8/fulltext

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.