Fertility drug use and the risk of ovarian tumors in infertile women: a case-control study

Data from a large U.S. case-control study of ovarian tumors revealed no significant association between fertility drug use and the risk of developing ovarian tumors among infertile women.


Albert Asante, M.D., M.P.H., Leonard H. Phoebe, M.D., Amy L. Weaver, Ellen L. Goode, Ph.D., M.P.H., Jani R. Jensen, M.D., Elizabeth A. Stewart, M.D., Charles C. Coddington, M.D.

Volume 99, Issue 7, Pages 2031-2036, June 2013



To assess the influence of infertility and fertility drugs on risk of ovarian tumors.


Case-control study (Mayo Clinic Ovarian Cancer Study).


Ongoing academic study of ovarian cancer.


A total of 1,900 women (1,028 with ovarian tumors and 872 controls, frequency matched on age and region of residence) who had provided complete information in a self-report questionnaire about history of infertility and fertility drug use.



Main Outcome Measure(s):

Effect of infertility history, use of fertility drugs and oral contraception, and gravidity on the risk of ovarian tumor development, after controlling for potential confounders.


Among women who had a history of infertility, use of fertility drugs was reported by 44 (24%) of 182 controls and 38 (17%) of 226 cases. Infertile women who used fertility drugs were not at increased risk of developing ovarian tumors compared with infertile women who did not use fertility drugs; the adjusted odds ratio was 0.64 (95% CI, 0.37, 1.11). The findings were similar when stratified by gravidity and when analyzed separately for borderline versus invasive tumors.


We found no statistically significant association between fertility drug use and risk of ovarian tumors. Further larger, prospective studies are needed to confirm this observation.

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Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00267-7/fulltext

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