Novel hormone treatment of benign metastasizing leiomyoma an analysis of five cases and literature review

Gonadotropin-releasing hormone agonist and/or an aromatase inhibitor treatment stabilized or improved disease in patients with benign metastasizing leiomyoma; a selective progesterone receptor modulator was associated with improved symptoms despite increasing fibroid size.

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Authors

Erin I. Lewis M.D., Rebecca J. Chason M.D., Alan H. DeCherney M.D., Alicia Armstrong M.D., John Elkas M.D., Aradhana M. Venkatesan M.D.

Volume 99, Issue 7, Pages 2017-2024, June 2013

Abstract

Objective:

To evaluate novel hormonal therapies in patients with unresectable benign metastasizing leiomyoma (BML) disease.

Design:

Case series.

Setting:

National Institutes of Health (NIH).

Patient(s):

Five subjects with the diagnosis of BML based on imaging and/or histopathologic diagnosis.

Intervention(s):

Four patients were treated with single or combination therapy of leuprolide acetate and/or an aromatase inhibitor. One patient was treated with an antiprogestin (CDB-2914).

Main Outcome Measure(s):

Response to therapy was measured by tumor burden on cross-sectional imaging employing RECIST (Response Evaluation Criteria in Solid Tumors) 1.1 guidelines.

Result(s):

Four patients treated with single or combination therapy of leuprolide acetate and/or an aromatase inhibitor demonstrated stable disease with reduction in tumor burden. The fifth patient treated with antiprogestin (CDB-2914) had degeneration of her tumor, progression of its size, and an improvement in symptoms.

Conclusion(s):

Hormone treatment with GnRH agonist and/or aromatase inhibition may be a therapeutic option to reduce tumor burden in unresectable BML disease or for those patients who wish to avoid surgical intervention. RECIST 1.1 guidelines, while traditionally used to evaluate tumor response to cancer therapeutics, may be useful in evaluating BML tumor burden response to hormone therapy.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00253-7/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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