Five years' experience using oocyte vitrification to preserve fertility for medical and nonmedical indications

Vitrification of oocytes is a reproducible, safe, and efficient method for fertility preservation in both oncological and nononcological patients, with a rapidly increasing demand and proven efficacy.


Juan Garcia-Velasco, M.D., Javier Domingo, M.D., Ana Cobo, Ph.D., Maria Martinez, M.D., Luis Carmona, Ph.D., Antonio Pellicer, M.D.

Volume 99, Issue 7, Pages 1994-1999, June 2013



To evaluate the results of controlled ovarian hyperstimulation (COH) for oocyte vitrification to preserve fertility for medical and nonmedical indications.


A retrospective, multicenter, observational study performed between March 2007 and June 2012.


University-affiliated infertility clinics.


Of 560 nononcological patients and 475 oncological patients, we performed 1,080 oocyte vitrification cycles, 725 for nonmedical reasons and 355 in patients affected for cancer. Cycle outcome is presented, including 30 women who returned to use their frozen eggs with, 20 pregnancies obtained, 6 newborns and 8 ongoing pregnancies.


Controlled ovarian hyperstimulation, oocyte retrieval, and warming of oocytes and embryo transfer in those who already came back.

Main outcome meausure(s):

Days of stimulation, total dose of gonadotropins, estrogen and progesterone levels, number of oocytes retrieved and vitrified, pregnancy rate.


Comparable results were obtained in both groups of patients, with lower total dose of gonadotropins used as well as lower serum estradiol level in patients affected with cancer. Frozen/thawed oocytes performed similarly in both groups.


Patients who vitrify eggs for medical or non-medical reasons perform similarly, as observed in this large series. This technique offers realistic expectations to both groups of patients to have a child with their own eggs. This data could be used to adequately counsel our patients.

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