The oncofetal protein IMP3: a novel biomarker and triage tool for premalignant atypical endometriotic lesions

Immunohistochemical staining for IMP3 is a simple, inexpensive, and sensitive test that can be used as a triage tool to discriminate between preneoplastic atypia and confounding benign conditions.

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Authors

Paolo Vercellini, M.D., Fulvia Milena Cribiù, M.D., Alessandro Del Gobbo, M.D., Maria Luisa Carcangiu, M.D., Edgardo Somigliana, M.D., Ph.D., Silvano Bòsari, M.D.

Volume 99, Issue 7, Pages 1974-1979, June 2013

Abstract

Objective:

To determine whether the oncofetal protein IMP3 is detectable in endometriomas with or without histological atypia and whether IMP3 staining can be used as a triage tool to identify foci of atypical endometriosis in doubtful cases.

Design:

Retrospective study.

Setting:

Academic department and referral center for endometriosis.

Patient(s):

A consecutive series of 516 women who underwent excision of 874 endometriomas.

Intervention(s):

Histological review by three expert pathologists and immunohistochemical staining for IMP3.

Main Outcome Measure(s):

Test performance of IMP3 immunohistochemistry versus first-round histology.

Result(s):

The prevalence of atypical endometriosis was 1.7% (95% confidence interval [CI], 0.9%–3.3%) based on the number of women and 1.0% (95% CI, 0.5%–1.9%) based on the number of cysts. Three cases of atypical endometriosis were identified at first-round histological examination. Immunohistochemistry detected seven of the eight cases diagnosed as preneoplastic atypia at second-round histology and one case diagnosed as reactive atypia at second-round histology. The sensitivity of first-round histology was 33.3%, compared with 88.9% of IMP3 immunohistochemistry.

Conclusion(s):

Immunohistochemical staining for IMP3 expression is a simple, inexpensive, and sensitive test that can be used in routine clinical practice as a triage tool to discriminate between cytological/structural atypia and confounding benign conditions.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00255-0/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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