Genetic variation in tissue inhibitors of metalloproteinases as a risk factor for idiopathic recurrent spontaneous abortion

There were no statistically significant differences in the distribution of genotype and allele frequencies of tissue inhibitors of metalloproteinases 1, 2, 3, and 4 gene polymorphisms between idiopathic recurrent spontaneous abortion couples and control subjects.

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Authors

Nina Pereza, M.D., Marija Volk, M.D., Nikolina Zrakić, Miljenko Kapović, M.D., Ph.D., Borut Peterlin, Ph.D., M.D., Saša Ostojić, Ph.D., M.D.

Volume 99, Issue 7, Pages 1923-1929, June 2013

Abstract

Objective:

To investigate the potential association of tissue inhibitor of metalloproteinases (TIMP) 1, 2, 3, and 4 gene polymorphisms with idiopathic recurrent spontaneous abortion (IRSA).

Design:

Case-control and association study.

Setting:

Departments of gynecology and obstetrics and university-based research laboratory.

Patient(s):

A total of 149 couples with a history of three or more idiopathic spontaneous pregnancy losses and 149 fertile men and 149 fertile women with at least two live births and no history of pregnancy pathologies.

Intervention(s):

Polymerase chain reaction and restriction-fragment-length polymorphism methods.

Main Outcome Measure(s):

Detection of TIMP-1 −372 C/T, TIMP-2 −303 C/T, TIMP-3 −915 A/G, TIMP-3 −1296 C/T, and TIMP-4 −3′-UTR C/T genotypes and allele frequencies.

Result(s):

There were no statistically significant differences in the distribution of any genotype and allele frequencies or any genetic model between IRSA patients and controls. Additionally, no significant associations occurred between combinations of TIMP polymorphisms and the risk of IRSA.

Conclusion(s):

We found no evidence for the association of TIMP-1, -2, -3, and -4 with IRSA in a Slovenian population.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00275-6/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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