Effect of prior birth and miscarriage frequency on the prevalence of acquired and congenital uterine anomalies in women with recurrent miscarriage: a cross-sectional study

Diagnostic imaging for congenital and acquired uterine anomalies should be recommended to women after two recurrent miscarriages, even if they have had a prior live birth.

Like Comment

Authors

Carolyn R. Jaslow, Ph.D., William H. Kutteh, M.D., Ph.D.

Volume 99, Issue 7, Pages 1916-1922.e1, June 2013

Abstract

Objective:

To determine whether a prior live birth or an increase in number of miscarriages impacted the prevalence of congenital or acquired uterine anomalies in women with predominantly early recurrent miscarriage (RM).

Design:

Single-center, cross-sectional study.

Setting:

Patients with RM at a private practice.

Patient(s):

Eight hundred seventy-five women who had two or more consecutive miscarriages.

Intervention(s):

None.

Main Outcome Measure(s):

Frequencies of congenital uterine anomalies (bicornuate, didelphic, septate, t-shaped, and unicornuate uteri) and acquired uterine anomalies (fibroids, polyps, and adhesions).

Result(s):

A uterine anomaly was identified in 169 (19.3%) of the patients. Patients with primary RM were more likely to have congenital anomalies than patients with secondary RM, particularly septa. The occurrence of a prior live birth, however, did not influence the frequency of acquired uterine anomalies, which were detected in equal frequencies in patients with three or more miscarriages when compared with patients with only two miscarriages.

Conclusion(s):

Although RM patients with a prior viable birth are less likely to have a uterine anomaly than those who have never given birth, our results support a recommendation for diagnostic imaging of the uterus after two losses in women with secondary RM as well as for those with primary RM.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00260-4/fulltext


Go to the profile of Fertility and Sterility

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.