Estrogen-suppressed in vitro maturation: a novel approach to in vitro maturation

Estrogen-suppressed in vitro maturation eliminates the need for gonadotropin stimulation and cycle monitoring yet results in a 40% live-birth rate.

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Authors

Wendy S. Vitek, M.D., Jeannine Witmyer, Ph.D., Sandra A. Carson, M.D., Jared C. Robins, M.D.

Volume 99, Issue 7, Pages 1886-1890, June 2013

Abstract

Objective:

To evaluate the laboratory and clinical outcomes of estrogen-suppressed in vitro maturation (ES-IVM), a novel IVM protocol that eliminates the need for FSH stimulation and cycle monitoring.

Design:

Case series.

Setting:

Academic infertility center.

Patient(s):

Eighteen infertile couples undergoing ES-IVM (n = 20). Eligible candidates included women ≤38 years old with either polycystic ovarian syndrome, antral follicle count ≥15, and/or history of ovarian hyperstimulation syndrome.

Intervention(s):

ES-IVM.

Main Outcomes Measure(s):

Oocyte yield, maturation, fertilization, embryo quality, implantation, clinical pregnancy, and live-birth rate were analyzed.

Result(s):

The average number of oocytes retrieved was 16.7 ± 5.9, with a 52.1% maturation rate and a 58% fertilization rate by intracytoplasmic sperm injection. The average number of embryos transferred was 2.85 ± 0.6. The implantation rate was 17.5%, the clinical pregnancy rate was 40%, and the live-birth rate was 40%.

Conclusion(s):

The efficiency of ES-IVM appears to be similar to natural cycle and low-stimulation IVM protocols with respect to laboratory and clinical outcomes, while eliminating the need for FSH stimulation and cycle monitoring.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00254-9/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.