Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index

Young and overweight women with PCOS generated thrombin faster than paired controls matched for age and body mass index.

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Maria Raquel Marques Furtado de Mendonça Louzeiro, M.D., Joyce Maria Annichino-Bizzacchi, M.D., Ph.D., Luís Alberto Magna, M.D., Ph.D., Susan Kelly Picoli Quaino, M.D., Cristina Laguna Benetti-Pinto, M.D., Ph.D.

Volume 99, Issue 6, Pages 1786-1790, May 2013



To evaluate hemostatic markers in women with polycystic ovary syndrome (PCOS) compared to healthy controls matched for age and body mass index.


Cross-sectional study.


Tertiary teaching hospital.


Forty-five women with PCOS and 45 controls paired for age (±2 years) and body mass index (BMI) (±2 kg/m2).


Clinical evaluation and venipuncture.

Main Outcome Measures:

Thrombin activatable fibrinolysis inhibitor, D-dimer, plasminogen activator inhibitor-1, and the thrombin generation test.


Thrombin generation lag-time was significantly shorter in women with PCOS compared to controls. The other hemostatic parameters were similar in both groups.


Thrombin generation is faster in young and overweight women with PCOS, suggesting a greater risk of hypercoagulability.

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Fertility and Sterility

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