Perinatal outcomes in 375 children born after oocyte donation: a Danish national cohort study

Children born after oocyte donation have a higher risk of preterm birth and low birth weight than after standard in vitro fertilization, mainly due to the risk of preeclampsia.

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Authors

Sara S. Malchau, M.D., Anne Loft, M.D., Elisabeth C. Larsen, M.D., Ph.D., Anna-Karina Aaris Henningsen, M.D., Steen Rasmussen, M.Sc., Anders Nyboe Andersen, M.D., D.M.Sci., Anja Pinborg, M.D., D.M.Sci.

Volume 99, Issue 6, Pages 1637-1643.e3, May 2013

Abstract

Objective:

To describe perinatal outcome in children born after oocyte donation (OD) compared to in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) and spontaneous conception (SC).

Design:

National cohort study.

Setting:

Danish fertility clinics.

Patients:

Three hundred seventy-five children born after OD during the period 1995–2010.

Interventions:

None.

Main Outcome Measures:

Mean birth weight, mean gestational age, risks of low birth weight (LBW), preterm birth (PTB), congenital malformations, Caesarian section, preeclampsia and admittance to neonatal intensive care unit.

Results:

We found an increased risk of PTB in OD pregnancies. The adjusted odds ratio (AOR) of PTB in OD singletons was 1.8 (95% CI, 1.2–2.69), 2.5 (95% CI, 1.7–3.6), and 3.4 (95% CI, 2.3–4.9) compared with IVF, ICSI, and SC, respectively. The risk of LBW was also increased. The AOR of LBW was 1.4 (95% CI, 0.9–2.2), 1.8 (95% CI, 1.2–2.8), and 2.6 (95% CI, 1.7–4.0) compared with IVF, ICSI, and SC. The risk of preeclampsia was increased in OD pregnancies with an AOR of 2.9 (95% CI, 1.8–4.6), 2.8 (95% CI, 1.7–4.5), and 3.1 (95% CI, 1.9–4.9) compared with IVF, ICSI, and SC. After additional adjustment for preeclampsia, perinatal outcome improved. Among the twins, the difference between the groups was less pronounced.

Conclusions:

OD pregnancies have poorer perinatal outcome than standard IVF and ICSI, mainly due to the high prevalence of preeclampsia.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00184-2/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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