Serum human chorionic gonadotropin levels on the day before oocyte retrieval do not correlate with oocyte maturity

Serum hCG levels on the day before oocyte retrieval do not correlate with oocyte maturity.

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Gary Levy, M.D., Micah J. Hill, D.O., Christina Ramirez, M.D., Torrie Plowden, M.D., M.P.H., Justin Pilgrim, D.O., Robin S. Howard, M.A., James H. Segars, M.D., John Csokmay, M.D.

Volume 99, Issue 6, Pages 1610-1614, May 2013



To evaluate the correlation of preretrieval quantitative serum human chorionic gonadotropin (hCG) level with oocyte maturity.


Retrospective Cohort Study.


Military ART program.


Fresh autologous ART cycles.


Serum hCG level the day before oocyte retrieval.

Materials and Methods:

Linear regression was used to correlate serum hCG and oocyte maturity rates. Normal oocyte maturity was defined as 75% and the Wilcoxon rank sum test was used to compare serum hCG in patients with normal and low oocyte maturity. Threshold analysis was performed to determine hCG levels that could predict oocyte maturity.


A total of 468 ART cycles were analyzed. Serum hCG level was not correlated with hCG dose; however, it was negatively correlated with body mass index (BMI). Serum hCG levels did not differ between patients with oocyte maturity of <75% and ≥75%. Serum hCG levels did not correlate with oocyte maturity rates. Receiver operator characteristic and less than efficiency curves failed to demonstrate thresholds at which hCG could predict oocyte maturity.


Serum hCG levels were not correlated with oocyte maturity. While a positive hCG was reassuring that mature oocytes would be retrieved for most patients, the specific value was not helpful.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.