Antimüllerian hormone levels decrease in women using combined contraception independently of administration route

In young healthy, normal weight women, continuous use of combined contraception leads to a decrease in serum AMH levels independently of administration route.

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Authors

Sanna Kallio, M.D., Johanna Puurunen, M.D., Aimo Ruokonen, M.D., Ph.D., Tommi Vaskivuo, M.D., Ph.D., Terhi Piltonen, M.D., Ph.D., Juha S. Tapanainen, M.D., Ph.D.

Volume 99, Issue 5, Pages 1305-1310, April 2013

Abstract

Objective:

To compare the effects of continuous use of oral, transdermal and vaginal combined contraceptives (CCs) on the pituitary-ovarian axis and inhibition of follicular development.

Design:

Spin-off study of a prospective, randomized trial.

Setting:

University clinic.

Patients:

Forty-two of 54 healthy women completed the study.

Interventions:

Treatment with combined oral contraceptives (ethinyl estradiol [EE] and desogestrel), transdermal patches (EE and norelgestromin) or vaginal rings (EE and etonogestrel) for 9 weeks continuously. Blood sampling was performed before and at 5 and 9 weeks of treatment.

Main Outcome Measures:

Changes in serum hormone levels induced by CCs.

Results:

Serum AMH, FSH, inhibin B, LH and estradiol (E2) levels had decreased significantly in all study groups after 9 weeks of treatment. Significant declines were already detected after 5 weeks’ use of CCs as regards all hormone levels apart from those of serum AMH, where the decrease between baseline and 5 weeks was only moderate. Between groups, serum levels of AMH, inhibin B, LH, and E2 were comparable at baseline and after 5 and 9 weeks of treatment.

Conclusions:

The decrease of serum AMH levels during the use of all CCs indicates that folliculogenesis is arrested independently of administration route.

Trial Registration Number:

NCT01087879

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)02446-6/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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