In vitro maturation of oocytes: uncommon indications

In vitro maturation may be an attractive option in patients suffering from ovarian resistance to FSH and for preserving fertility in combination with ovarian tissue cryopreservation.

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Michael Grynberg, M.D., Ph.D., Hady El-Hachem, M.D., Astrid de Bantel, M.D., Julie Benard, M.D., Soizic le Parco, M.D., Renato Fanchin, M.D., Ph.D.

Volume 99, Issue 5, Pages 1182-1188, April 2013


Retrieval of immature oocytes from unstimulated ovaries, followed by in vitro maturation (IVM) was initially proposed to avoid the risks and side effects of exogenous gonadotropin administration. Therefore, over the past decades, IVM was mainly offered in PCOS patients at high risk of ovarian hyperstimulation syndrome. However, the development of fertility preservation has recently open new perspectives in the field of IVM. The present review summarizes uncommon indications of IVM, which is a viable option to treat infertility in patients with ovarian resistance to FSH, but may also be considered to preserve fertility in leukemia as well as before ovarian transposition and endometrioma excision.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility┬« is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.