Polycystic ovary syndrome offspring display increased oxidative stress markers comparable to gestational diabetes offspring

The present study demonstrated that in PCOS neonates, the oxidative stress status was similar to that of GDM neonates and strongly associated with their mothers’ oxidative status.


Georgios Boutzios, M.D., Sarantis Livadas, Ph.D., Christina Piperi, Ph.D., Nicolaos Vitoratos, Ph.D., Christos Adamopoulos, Dimitrios Hassiakos, Ph.D., Christos Iavazzo, Ph.D., Evanthia Diamanti-Kandarakis, Ph.D.

Volume 99, Issue 3, Pages 943-950, 1 March 2013



To study oxidative stress (OS) markers on neonates. The specific aim was to evaluate advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) serum levels along with the hormonal/metabolic profile and their possible relationship in a cohort of polycystic ovary syndrome PCOS(N) and gestational diabetes GDM(N) neonates and their mothers PCOS(M) & GDM(M).


Prospective controlled study.


Academic medical center.


The study population comprised 151 mothers/neonates pairs.


Diet and/or insulin administration in GDM(M).

Main Outcome Measures:

Anthropometric, metabolic, hormonal parameters and OS markers.


AGEs and AOPPs were higher in PCOS(M) and GDM(M) compared to controls (M) (p<0.05. The same significant difference (p<0.05) was observed in the corresponding groups of neonates. A strong relationship between mothers and neonates regarding AGEs (r=0.605, p<0.001) and AOPPs levels (r=0.735, p<0.001) was disclosed. Analogous findings were observed regarding androgens and insulin resistance in mothers and neonates, respectively. Conclusion:

The present study demonstrated that in PCOS(N), the OS status was similar to that of GDM(N) and strongly associated with their mothers’ oxidative status. These findings may have clinical implications, since exposure of PCOS(N) to high OS levels during pregnancy could affect several health issues of neonates.

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