Null genotypes of GSTM1 and GSTT1 contribute to male factor infertility risk a meta analysis

We discuss evidence that the null of GSTM1 and GSTM1-GSTM1 increased the risk of male factor infertility, but the null genotype of GSTT1 was not associated with an increased infertility risk.

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Authors

He-Ping Kan, M.D., Fang-lei Wu, M.M., Yong-zhong Wang, M.D., Wen-bin Guo, M.M., Jing-ping Li, M.M., Yu-qi Huang, M.D., Shu-guang Li, M.D., Jian-ping Liu, M.D.

Volume 99, Issue 3, Pages 690-696, 1 March 2013

Abstract

Objective:

To study the null of GSTM1, GSTT1 or GSTT1-GSTM1 and the risk of male infertility.

Design:

Meta-analysis using electronic database (Pubmed, Medline, Embase, and China National Knowledge Infrastructure) up to August 22, 2011.

Setting:

The strength of the relationship between null of GSTM1, GSTT1or GSTT1-GSTM1 and the risk of male infertility were assessed by Odds Ratio (ORs). A total of 16 studies were identified in this meta-analysis. (Among the 16 studies, 15 studies reported GSTM1null, 10 GSTT1 and 5 GSTM1-GSTT1).

Intervention(s):

Meta-analyses by means of random-effects models and fixed-effects models.

Main outcome measure(s):

Ratio of male infertility.

Result(s):

The studies provided overall ORs estimates for GSTM1, GSTT1 and GSTM1-GSTT1, leading to a pooled OR of 1.41 (95% confidence interval (CI), 1.10 -1.81), 1.15 (95% (CI), 0.95–1.39), 2.99(95% (CI), 2.14 -4.18), respectively.

Conclusion(s):

There were evidences that the null of GSTM1 and GSTM1- GSTT1 increasing the risk of male infertility, but GSTT1. We still need further multicentres and better-controlled studies to confirm these findings.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)02349-7/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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