Null genotypes of GSTM1 and GSTT1 contribute to male factor infertility risk a meta analysis

We discuss evidence that the null of GSTM1 and GSTM1-GSTM1 increased the risk of male factor infertility, but the null genotype of GSTT1 was not associated with an increased infertility risk.

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He-Ping Kan, M.D., Fang-lei Wu, M.M., Yong-zhong Wang, M.D., Wen-bin Guo, M.M., Jing-ping Li, M.M., Yu-qi Huang, M.D., Shu-guang Li, M.D., Jian-ping Liu, M.D.

Volume 99, Issue 3, Pages 690-696, 1 March 2013



To study the null of GSTM1, GSTT1 or GSTT1-GSTM1 and the risk of male infertility.


Meta-analysis using electronic database (Pubmed, Medline, Embase, and China National Knowledge Infrastructure) up to August 22, 2011.


The strength of the relationship between null of GSTM1, GSTT1or GSTT1-GSTM1 and the risk of male infertility were assessed by Odds Ratio (ORs). A total of 16 studies were identified in this meta-analysis. (Among the 16 studies, 15 studies reported GSTM1null, 10 GSTT1 and 5 GSTM1-GSTT1).


Meta-analyses by means of random-effects models and fixed-effects models.

Main outcome measure(s):

Ratio of male infertility.


The studies provided overall ORs estimates for GSTM1, GSTT1 and GSTM1-GSTT1, leading to a pooled OR of 1.41 (95% confidence interval (CI), 1.10 -1.81), 1.15 (95% (CI), 0.95–1.39), 2.99(95% (CI), 2.14 -4.18), respectively.


There were evidences that the null of GSTM1 and GSTM1- GSTT1 increasing the risk of male infertility, but GSTT1. We still need further multicentres and better-controlled studies to confirm these findings.

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Fertility and Sterility

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