Ovulation induction and epigenetic anomalies

This systematic review summarizes the current knowledge about the potential epigenetic effects of ovulation induction during gametogenesis and also during implantation and postimplantation periods.

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Authors

Patricia Fauque, M.D., Ph.D.

Volume 99, Issue 3, Pages 616-623, 1 March 2013

Abstract

This systematic review reports the effects of ovulation induction on epigenetic control. Studies mainly done in the mouse model highlight that hormonal treatments may be per se prejudicial to the epigenetic reprogramming of the gametes as well as of the early embryos. Moreover, hormonal protocols used in assisted reproduction may also modify the physiological environment of the uterus potentially linked to endometrial epigenetic disturbances. Nowadays, the little data available in humans does not allow us to independently determine the impact of the woman’s age, infertility problems, protocols and doses of hormonal treatments on processes including genomic imprinting, and therefore emphasizes the need for further studies on humans.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00009-5/fulltext


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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