Metformin decreases serum 8 hydroxy 2 deoxyguanosine levels in polycystic ovary syndrome

A double-blind, randomized, placebo-controlled trial on the effects of metformin on serum levels of 8-hydroxy-20-deoxyguanosine (8-OHdG) in women with polycystic ovary syndrome showed levels were statistically significantly reduced versus placebo.

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Henri Sova, M.B., Ulla Puistola, M.D., Ph.D., Laure Morin-Papunen, M.D., Ph.D., Peeter Karihtala, M.D., Ph.D.

Volume 99, Issue 2, Pages 593-598, February 2013



To learn whether metformin treatment affects oxidative stress as measured by serum concentrations of 8-hydroxy-2′-deoxyguanosine (8-OHdG).


Double-blind, randomized, placebo-controlled trial.


University outpatient clinic.


The study cohort consisted of 50 obese women (body mass index [BMI] ≥27 kg/m2) and 60 nonobese patients (BMI <27 kg/m2), mean age was 27.7 ± 4.0 SD years. Interventions:

Women were randomized to receive metformin or placebo for 3 months.

Main Outcome Measure(s):

Serum levels of 8-OHdG before and after medical treatment.


The levels of 8-OHdG were equal at baseline in the placebo and metformin groups. Obese women had higher baseline serum concentrations of 8-OHdG. Levels of 8-OHdG were statistically significantly reduced with metformin treatment, especially in obese patients with polycystic ovary syndrome. This study was a secondary subanalysis of a previously conducted prospective multicenter, randomized, placebo-controlled study on the effects of metformin on miscarriage, pregnancy, and miscarriage rates.


Metformin treatment, compared with placebo, significantly decreased 8-OHdG levels in women with PCOS.

Clinical trial registration number:


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