Markedly elevated soluble E cadherin in plasma of patient with pelvic inflammatory disease

The level of plasma soluble E-cadherin was elevated in patients with pelvic inflammatory disease as compared with that in normal controls and in the same patients after they received treatment.

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Authors

Hsiu-Ting Tsai, Ph.D., Tsung-Hsien Lee, M.D., Ph.D., Shun-Fa Yang, Ph.D., Long-Yau Lin, M.D., Sc.D., Yi-Torng Tee, M.D., Ph.D., Po-Hui Wang, M.D., Ph.D.

Volume 99, Issue 2, Pages 490-495, February 2013

Abstract

Objective:

To estimate the expression of plasma soluble E-cadherin and the gene polymorphism in patients with pelvic inflammatory disease (PID).

Design:

Hospital-based case-control study.

Setting:

University hospital.

Patient(s):

Sixty-four women with PID.

Intervention(s):

Blood specimen collection of patients before and after they received treatment.

Main Outcome Measure(s):

Enzyme-linked immunosorbent assay and polymerase chain reaction–restriction fragment length polymorphism were respectively used to measure the plasma soluble E-cadherin level and E-cadherin polymorphism.

Result(s):

The level of plasma E-cadherin was significantly elevated in PID patients as compared to that in normal controls; it decreased significantly after treatment when compared to levels noted in same patients after they received treatment. When the cutoff level of plasma E-cadherin level was set to be 20.22 ng/ml based on ROC, the sensitivity, specificity, and the area under the curve of plasma E-cadherin level for predicting PID were 0.81, 0.80, and 0.835 (95% confidence interval (CI), 0.76-0.90). The adjusted odds ratio (AOR) for age, WBC, and CRP levels is 19.66 (5.48-70.47).

Conclusion(s):

Elevated plasma soluble E-cadherin expression was involved in the pathogenesis of PID and useful for the diagnosis of PID.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)02310-2/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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