Preliminary results of the first human uterus transplantation from a multiorgan donor

We report the first-year results of the longest-lived human uterus allograft.

Like Comment

Authors

Omer Ozkan, M.D., Munire Erman Akar, M.D., Ozlenen Ozkan, M.D., Okan Erdogan, M.D., Filiz Gunseren, M.D., Mehmet Cincik, M.D., Elif Pestereli, M.D., Huseyin Kocak, M.D., Necmiye Hadimioglu, M.D., Murat Yilmaz, M.D., Derya Mutlu, M.D., Gamze Bektas, M.D., Ayhan Dinckan, M.D., Omer Gecici, M.D., Gultekin Suleymanlar, M.D.

Volume 99, Issue 2, Pages 470-476.e5, February 2013

Abstract

Objective:

To describe the first-year results of the first human uterus transplantation case from a multi-organ donor.

Design:

Case study.

Setting:

University hospital.

Patient(s):

A 21-year-old female patient with complete mullerian agenesis who had been previously operated on for vaginal reconstruction.

Intervention(s):

Uterus transplantation procedure consisting of orthotopic replacement and fixation of the retrieved uterus, revascularisation, end to site anastomoses of bilateral hipogastric arteries and veins to bilateral external iliac arteries and veins was performed.

Main outcome measure(s):

Resumption of menstrual cycles.

Results:

The patient had menarche 20 days after transplant surgery. She has had 12 menstrual cycles since the operation.

Conclusion:

We have described the longest-lived transplanted human uterus to date with acquirement of menstrual cycles.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)02254-6/fulltext


Go to the profile of Fertility and Sterility

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.